A ''Sexually Transmitted'' Fixed Drug Reaction

摘要

Fixed drug eruption (FDE) is a common adverse drug reaction that occurs and recurs with exposure to the offending agent.1 Its exact pathogenesis remains mostly misunderstood.2 We report a case of FDE on the penile shaft of a patient caused by ingestion of diclofenac by the sexual partner. A 37-year-old man presented with a 7-day history of a penile lesion. His medical history was unremarkable, and he denied taking any medications in the last 8 months. His only sexual partner, his wife, is healthy apart from the occasional self-medication using diclofenac for cervicalgia. Clinical examination showed a discrete postinflammatory hyperpigmentation. The patient reports that he had noticed the same lesion 2 months prior and was convinced that his disease was sexually transmitted. Complete blood workup and routine urinalysis revealed no abnormalities. HIV antibodies, venereal disease research laboratory test, and immunoglobulins G and M against human herpes simplex viruses were all negative.