Influence of solvent choice on the optimisation of a reaction-separation operation:application to a BECKMANN REARRANGEMENT REACTION

摘要

In pharmaceutical syntheses,the solvent choice generally represents a complex design step.Traditionally,this choice is operated according to criteria connected with the reaction step and without any consideratin on the following separation steps.The purpose of this study is to highilght the benefits of a global approach of optimistion for the solvent determination.In this way,an optimisatin framework dedicated to global synthesis is applied to a simple reactin-separatin operation integrating a beckmann rearrangement reaction,leading to interesting solvent choices.