Since the last Seminars in Liver Disease special issue devoted to hepatitis B in 2006, two doyens of the field have passed away: Professor Barry Blumberg on April 5, 2011 and Professor R. Palmer Beasley on August 25, 2012. Both made enormous contributions to human health. By discovering and then successfully implementing the world's first anticancer vaccine, they helped many millions of people around the world enjoy a life free from the sequelae of chronic hepatitis B virus (HBV) infection. The editors wish to dedicate this special issue to Professor Blumberg and Professor Beasley.
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