KINETIC AND MECHANISTIC STUDIES ON THE OXIDATION OF CHLORAMPHENICOL DRUG BY MANGANESE(III) PYROPHOSPHATE IN PHOSPHORIC ACID-WATER MEDIUM

摘要

Chloramphenicol (CAP) is an antibiotic drug having a wide spectrum of activity. Mechanistic studies on the oxidation of chloramphenicol (CAP) drug by manganese(III) pyrophosphate (Mn(III)py3) in phosphoric acid-water medium have been performed. The reaction exhibits complex formation, first order dependence on [Mn(III)py3] and zero order dependence on [CAP]. The oxidation rate is positively influenced by acidity and the order with respect to H~+ is fractional. The effects of [MnSO4] and [Na2SO4] have been studied. The effects of the dielectric constant of the medium and the ionic strength indicate the reaction to be of ion-ion type. The stoichiometry of the reaction is 1:1 and the product of oxidation is an aldehyde. Activation energy and various thermodynamic parameters have been evaluated. A suitable mechanism has also been suggested.