The effect of iron incorporation on the in vitro bioactivity and drug release of mesoporous bioactive glasses

摘要

Magnetic mesoporous bioactive glasses with the composition xFe-(80 - x)SiO_2-15CaO-5P_2O_5 (mol%) (Fe/MBGs) were prepared by the non-ionic block copolymer EO_(20)PO)_(70)EO_(20) (P123) surfactant as template and the evaporation-induced self-assembly process using Ca, P, Si and Fe sources. The structure, morphology and magnetic properties of Fe/MBGs were characterized by X-ray diffraction, scanning electron microscopy, infrared spectra, vibrating sample magnetometer and N_2 adsorption-desorption technique. The results show that Fe/MBGs have porous network (pore diameter of 50-100 nm), mesoporous walls (mesoporous size of 4-5 nm), and that the mesostructure, magnetic properties and in vitro bioactivity of the Fe/MBGs depend on the chemical composition. Furthermore, the Fe incorporation in the MBGs enhanced the magnetic properties, demonstrated sustained drug delivery and maintained apatite-formation ability in SBF. This means that the Fe/MBGs allowed bioactivity could improve their drug delivery capacity, thus enhancing their potential applications as bioactive filler materials for bone tissue regeneration.