Bone Morphogenic Protein 3 Signaling in the Regulation of Osteogenesis

摘要

Bone morphogenic protein (BMP) 3 is the most abundant BMP in bone, accounting for >65% of the total BMP stored in the bone matrix. Bone morphogenic protein 3 plays a role in fracture healing, mechanical loading of the skeleton, development, and osteoporosis. Bone morphogenic protein 3 inhibits osteoblast differentiation and is thus a negative regulator of bone density. Understanding how BMP-3 diminishes bone mass has significant clinical implications.