Nociceptors in the joint capsule, ligaments, synovium, and sub-chondreal bone are thought to be core to osteoarthritic pain. In contrast with pain syndromes such as fibromyalgia and chronic low back pain, in osteoarthritis (OA) the cause of the pain is observable. Therefore, the most obvious way to reduce the pain appears to search for pharmacological and surgical interventions that target the damaged tissues or that prevent further tissue damage. However, the origin of pain in patients with radiographic OA is not well understood. Although in the long run, definitive structural radiographic signs of OA such as joint space narrowing or eburna-tion on a peripheral joint are associated with a risk of developing pain, frequently the correlation between the structural alterations on radiography and pain is low
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