Sequential insertion of carbon monoxide and imines into nickel-methyl bonds: A new route to imine hydroacylation

摘要

The sequential insertion of carbon monoxide and imines has been achieved at ambient temperatures with cationic nickel complexes, yielding the nickel-chelated amides (bipy)Ni[eta (2)-C(H)TolN(R)COCH3]X-+(-) (bipy = 2,2'-bipyridyl; Tol = p-tolyl; R = alkyl, aryl; X = OTf, PF6, SbF6, B(3,5-C6H3(CF3)(2))(4)). The addition of KCN/methanol to these products of CO/imine insertion leads to cleavage of the amide ligand, providing a facile method to achieve the overall hydroacylation of imines under mild conditions. [References: 33]