Carbon-Carbon Bond Formation through Double sp~2 C-H Activations:Synthesis of Ferrocenyl Oxazoline Derivatives

摘要

Direct arylation of simple arenes with ferrocenyl oxazolines was achieved in the presence of a stoichiometric amount of Pd(OAc)_2 or a catalytic amount of palladium with excess oxidant such as Cu(OAc)_2.This double sp~2 C-H activation process provides a unique access to the aryl-substituted ferrocene derivatives,even in the enantiopure form of planar chirality,in a few steps from readily available starting materials.