Asymmetric Synthesis of β-Amino Alcohols by Reductive Cross-Coupling of Benzylideneamine with Planar Chiral Benzaldehydes

摘要

Samarium iodide mediated reductive cross-coupling of N-tosyl benzylideneamine with benzaldehydes or the corresponding chromium complexes gave syn-β-amino alcohol derivatives. A dynamic kinetic resolution of a configurationally equilibrated reactive species occurred in the crosscoupling with planar chiral benzaldehyde chromium complexes.