A Synthetic Strategy for the Cyclodepsipeptide Core of the Antitumor Antibiotic Verucopeptin

摘要

An efficient [2+2+2]-fragment condensation strategy is described for obtaining the cyclodepsipeptide core of verucopeptin.The 19-membered macrocycle was established through a Carpino HATU mediated macrolactamization,which proceeded in good yield under high-dilution conditions.