Palladium-Catalyzed Arylation of α-Methylene-γ-butyrolactone: 3-Benzylfuran-2(5H)-ones vs (Z)-Benzylidene-γ-butyrolactones and Their Reduction to 3-Benzyl-γ-butyrolactones

摘要

The palladium-catalyzed arylation of the α-methylene-γ-butyrolactone proceeds in good yields and may be directed toward the synthesis of 3-benzylfuran-2(5H)-ones when the starting aryl iodides contain strongly electron-withdrawing groups. The combined palladium-catalyzed arylation/hydrogenation of the α-methylene-γ-butyrolactone represents a new simple entry into functionalized α-benzyl-γ-butyrolactones.