Convenient Synthesis of Polyfunctionalized β-Fluoropyrroles from Rhodium(II)-Catalyzed Intramolecular N-H Insertion Reactions

摘要

Polyfunctionalized β-fluoropyrrole can be readily prepared from rhodium(II) acetate-catalyzed intramolecular N-H insertion reaction of δ-amino-γ,γ-difluoro-α-diazo-β-ketoesters. A cyanomethylene group can be introduced at C-3 of the pyrrole ring through the Wittig reaction of the diazo compounds followed by rhodium(II)-catalyzed intramolecular N-H insertion reactions.