Novel One-Pot Synthesis of 3-Amino-1-alkenylphophonates by Addition of Imines to Alkynylphosphonate Titanium(II) Complexes

摘要

A new method of synthesis of 3-amino-1-alkenylphosphonates is described. It involves the addition of imines to the alkynylphosphonate titanium(II) complexes 2, which are prepared in situ from 1-alkynylphosphonates and Ti(O-i-Pr)_4/2 equiv of i-PrMgCl. Compounds 4a-i were obtained regio- and stereoselectivity in high yields.