Aerobic Oxidative Cyclization under Pd(Ⅱ) Catalysis: A Regioselective Approach to Heterocycles

摘要

An efficient Yb(OTf)_3-promoted palladium-catalyzed oxidative cyclization of γ-heteroalkenyl β-keto amides has been developed. Under simple aerobic condition, a variety of six-, seven-, and eight-membered-ring N- and O-heterocycles were obtained regioselectively in excellent yield.