Highly Diastereoselective and Enantioselective Synthesis of Enantiopure C_2-Symmetrical Vicinal Diamines by Reductive Homocoupling of Chiral N-tert-Butanesulfinyl lmines

摘要

An efficient and straightforward method for the preparation of highly enantiomerically enriched C_2-symmetrical vicinal diamines by the reductive homocoupling of aromatic N-tert-butanesulfinyl imines in the presence of Sml_2 and HMPA was developed.It gives access to a variety of enantiopure(C_2-symmetrical 1,2-diamines in a very mild and practical way.