Novel[2+2+2+1]Cycloaddition of Enediynes Catalyzed by Rhodium Complexes

摘要

The first Rh-catalyzed intramolecular[2 + 2 + 2 + 1]cycloaddition reaction of enediynes and CO is reported.This novel higher order cycloaddition process gives the corresponding 5-7-5 ring systems in high yield and selectivity.This process is another significant addition to the arsenal of cycloaddition-based synthetic methods,which provide powerful tools for rapid and efficient construction of complex polycyclic systems.