Palladium-Catalyzed Cross-Coupling Reaction of Triorganoindium Reagents with Propargylic Esters

摘要

Triorganoindium reagents (R_3ln) react with propargylic esters under palladium catalysis via an S_N2' rearrangement to afford allenes in good yields and with high regioselectivity.The reaction proceeds smoothly at room temperature with a variety of R_3ln (aryl,alkenyl,alkynyl,and methyl).When chiral,nonracemic propargylic esters are employed,the reaction takes place with high anti-stereoselectivity providing allenes with high enantiomeric excess.