Some recent approaches m the design of synthetic anti-tubercular agents containing five membered heterocycles rings

摘要

The valuable treatment of tuberculosis is difficult, due to the complicated or unusual structure and chemical composition of the mycobacterial cell wall. These complex properties of cell wall make many antibiotics and currently used drugs ineffective and hinder the entry of drugs in to the myco-bacterium cells. Tuberculosis is still the one of the most crucial infectious disease worldwide. The most important complication in the treatment of tuberculosis is drug resistant multidrug (MDR-TB) and extensive drug resistant tuberculosis (XDR-TB), persistent infection or latent-TB and synergism of TB with Human Immuno deficiency Virus (HIV). New chemical entities are required for the MDR-TB and XDR-TB. Furthermore not any new chemical entity has come in last 40 years for pontent and effective antitubercular drug against resistant strain. Currently available data from the recently doveloped antitubercular drugs which containing five membered heterocyclic ring system. The modern drug design promises to bring significant development for effectiveness against tuberclosis. In present review we discussed brief introduction of recently doveloped antitubercular agents containing five membered heterocylic rings in their structures.