Author’s reply to comment on ‘‘The effect of photodynamic therapy on tumor angiogenesis. Cellular and Molecular Life Sciences, 66, 2275–2283’’

摘要

The comments by Nowak-Slieinska et al. are an extension of our review article. We agree with the authors that vascular normalization is an important event that decides the outcome of anti-angiogenesis therapies. As reported by Jain RK et al. [1], antiangiogenic agents can normalize the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery.Therefore, induction of vascular normalization caused by anti-angiogenic agents provides a novel means of effective delivery of chemotherapeutic drugs. Our report was based on the effective use of anti-angiogenesis therapy to improve therapeutic efficacy of PDT. The authors agree that the use of anti-angiogenesis agents before PDT to induce vascular normalization and increase the homogenous effect of oxygen-dependent PDT is an interesting hypothesis that is worth pursuing.