Putting Two Heads Together to Unwind DNA

摘要

The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2–7 replicative helicase encircles doublestranded DNA as head-to-head double hexamers.