The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors.

摘要

We have recently reported that lowering the pH to values that are frequentlydetected in tumors causes reversible anergy in both human and mouse CD8(+) Tlymphocytes in vitro. The same occurs in vivo, in the tumor microenvironment and the administration of proton pump inhibitors, which buffer tumor acidity, canrevert T-cell anergy and increase the efficacy of immunotherapy.