NKG2D ligands link oncogenic RAS to innate immunity.

摘要

RAS is constitutively active in multiple types of tumor cells. We have recentlydemonstrated that H-RASV12 enhances the translation of ligands for the activatingimmune receptor NKG2D, hence rendering cells more susceptible to natural killer(NK) cell-mediated lysis. This effect depends on MAPK and PI3K signaling, but noton the DNA damage response.