A co-stimulatory trap set by myeloid leukemia cells.

摘要

The straightforward notion that tumor cells always exert immunosuppressivefunctions has been contradicted by the finding that myeloid leukemia cells canexpress potent co-stimulatory molecules. Indeed, the co-stimulatory supportoffered by leukemia cells can provoke helper T-cell responses. Unfavorably, this interaction allows leukemia cells to acquire immunosuppressive capacities.