Importance of helper T-cell activation in dendritic cell-based anticancerimmunotherapy.

摘要

Dendritic cell-based anticancer immunotherapy is feasible, safe and results inthe induction of tumor-specific immune responses, at least in a fraction ofvaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the correspondingmRNAs, may further enhance vaccine-induced antitumor responses.