The adenosinergic system in cancer: Key therapeutic target.

摘要

High amounts of adenosine are released in the tumor mass. Depending on the levelsof adenosine, as well as on the receptor subtypes that are expressed by immunecells, adenosine can affect tumor growth in different fashions. Specificallytargeting CD73, the rate-limiting enzyme for the extracellular generation ofadenosine, or the A3 receptor offers new therapeutic strategies to limit tumorprogression.