Acoustical studies of molecular interaction in the solution of propranolol hydrochloride drug at different temperatures and concentrations

摘要

In the present study ultrasonic velocity (upsilon), density (rho) and viscosity (eta) have been measured at 1MHz frequency in the binary mixtures of propranolol hydrochloride with water in the concentration range (0.1 to 0.0125%) at 303, 308, 313 K using multifrequency ultrasonic interferometer. The measured value of density, ultrasonic velocity, and viscosity have been used to calculate the acoustical parameters namely adiabatic compressibility (beta(a)), relaxation time (tau), acoustic impedance (z), free length (L (f) ), free volume (V (f) ) and internal pressure (DY (i) ), Wada's constant (W), Rao's Constant (R), and cohesive energy (CE). These parameters explained formation of hydrogen bond and molecular interaction existing in the solution.