Synthetic Approach to Preparation of Indole Derivatives Fused with a Bicyclo[3.3.1]nonane Framework

摘要

Starting with DELTA~(15)-17-ketosteroids,applying Normant reaction with allylmagnesium bromide and anionic Cope rearrangement of the formed allyl alcohol,15a-derivatives of androstane series were prepared.The latter were brought into Wittig reaction with an yLide generated from,ethyltriphenylphosphonium bromide,and the product was subjected to ene reaction to provide 15 alpha-substituted pregnanes.