Reactions of Lithiated Allenes with Isothiocyanates:First Example of Hydrolysis of 2,3-Dihydropyridines as a Novel Synthetic Route to 5,6-Dihydropyridin-2(1H)-ones

摘要

Pyridine derivatives,including pyridinones and dihydropyridinones,are key structural fragments in many natural biologically active compounds and most important medical agents,specifically anti-HIV preparations [1].Therefore,search and design of radically new and simultaneously simple and highly efficient synthetic approaches to these compounds,as well as extension of their assortment,constitute an actual problem.