Synthesis of 2,4,6(1H,3H,5H)-Pyrimidinetrione-5-carboxaldehyde

摘要

Continuing our research in the field of pyri-midine-5-carboxaldehydes, we faced the necessity to synthesize pyrimidine-2,4,6(1H,3H,5H)-trione-5-carbo-xaldehyde I. Among the methods, described for obtaining I, we have chosen the one, based on the alkaline hydrolysis of 5-phenylaminomethylene-pyrimidine-2,4,6 (1H,3H,5H)-trione II, which, in turn, can be prepared by three-component condensation of pyrimidine-2,4,6(1H,3H,5H)trione (III), triethoxy-methane and aniline.