Desilylation of β-Cyclodextrin Derivative via Reaction with Phenylphosphonous Acid Dichloride

摘要

We previously found that cyclophosphorylation at the secondary hydroxy groups of β-cyclodextrin silyl derivative I with phenylphosphonous dichloride II is unexpectedly accompanied by an appreciable desilylation [1]. Based on some experimental data, we suggests that the desilylation act (second phase) is preceded by a specific supramolecular reorganization of the intermediately formed conjugate [chemically bound cyclodextrin derivative I (host) and chloro-phosphonite residue II (guest) (stage I)].