Reaction of Thiosemicarbazide with Methyl Phenylpropynoate:Synthesis of 1,3-Thiazinone Derivatives

摘要

Condensation of thiourea with acetylenecarboxylic acid esters is well known and is used in synthesis of l,3-thiazin-4-ones [1-4].It is also known that N-ami-nothiourea (thiosemicarbazide,I)reacts with methyl propynoate in methanol to form methyl 3-thiosemicar-bazonopropanoate [5].Therefore,proceeding with studies on synthetic routes to potentially bioactive 1,3-thiazinones and condensed systems based on them,we studied the reaction of I with methyl phenyl-propynoate II.