Cationic Phospholipids on the Basis of Higher Fatty Alcohols

摘要

A perspective synthetic approach to cationic amidodiester lipid constructions on the basis of cyclic phosphites derived from octadecan-1-ol is presented.The syntheses of phospholipids were carried out by oxidative decyclization of cyclic phosphoramidites with bromine.One of the important priorities of modern lipido-logy is synthesis of cationic ammonium analogs of natural phospholipids,as promising starting materials for genosome design and objects for other biomedical studies.