Acetals and N,N'-Alkylidenebiscarbamates in the Synthesis of N-Protected α-Aminophosphinic Acids

摘要

A convenient procedure of the amide version of the Kabachnik-Fields reaction is a promising approach to the synthesis of N-protected a-aminophosphorylic compounds. The amidoalkylation originally suggested for the phosphorous chlorides in acetic acid (the Oleksyszyn reaction) [1] was later modified to the amidoalkylation of dialkylphosphites in acetyl chloride or in a mixture of acetic acid and thionyl chloride involving the carbonyl compounds and amides [2].