Alkylation of 5-Amino-1,2,4-triazole with 1,2-Dibromoethane

摘要

Azoles containing an NH pyridine nitrogen atom, along with a pyrrole group, can be alkylated under neutral conditions [1]. The reaction in this case is directed on the azo group and leads to formation of a quaternary salt which is treated with a base to isolate an N-substituted compound. Moreover, since aminotriazoles are relatively highly basic compounds capable of salt formation, then the role of the base can be played by excess heterocycle.