Synthesis and Some Reactions of 2-[4-(2-Chlorobenzyl)-6,6-dimethyltetr ahy dropyr an-4-yl] ethylamine

摘要

In extension of the search for biologically active compounds, 4-aryl-substituted amines of tetrahydro-pyran series have been synthesized [1,2]. Previously synthesized ethyl cyano(2,2-dimethyl-tetrahydropyran-4-ylidene)acetate I [3] reacts with 2- chlorobenzylmagnesium chloride to form ethyl cyano-[2,2-dimethyltetrahydropyran-4-yl-4-(2-chlorophenyl)]-acetate Ⅱ.