Convenient Synthesis of Allobetulin

摘要

Synthetic transformations of plant triterpenoid betulin I widespread in nature and easily isolated in the pure form are promising for creating new and effective medicines [1]. Betulin I and its derivatives possess antiinflammatory, hepatoprotective, antiviral, antitumor and anti-HIV activity [2-4]. Allobetulin II, an isomerization product of betulin I, also exhibits diverse biological activity (antifeedant, antiulcer, antiviral, cytotoxic, etc.) and is used in the synthesis of pharmaceutically valuable and natural products [5-16].