Polyfunctional Derivatives of Isocytosine.Effect of Hydration on Prototropic Tautomerism of 2-(2-Hydroxyethyl)amino-6-methylpyrimidin-4(3H)-one

摘要

Hydration of 2-(2-hydroxyethyl)amino-6-methylpyrimidin-4(3H)-one forms an equilibrium mixture of 4-oxo-3,4-dihydro and 4-hydroxy tautomers.The intermediate in mutual transitions of these tautomers has a zwitter ionic structure.The equilibrium shifts to the 4-oxo-3,4-dihydro form as the polarity of the medium decreases.