Synthesis and Properties of 2-Substituted 5-Chloro-1,3-oxazole-4-earboxamides

摘要

Chlorination of 2-aryl-5-benzylsulfanyl-1,3-oxazole-4-carbonitrile in aqueous acetic acid at 50-60°C afforded new 2-aryl-5-chloro-1,3-oxazole-4-carboxamides. The reactivity of the chlorine atom with respect to the N-, O-, and S-nucleophiles was investigated.