Unusual Chemical Behavior of 1-(2-Chloroethyl)-4-hydroxymethylpyrazoles at Heating

摘要

Previously we have shown that 1-(2-chloroethyl)-3,5-dimethyl-4-hydroxymethylpyrazole is thermally unstable and undergoes some transformation when distilling [1]. To investigate the nature of the observed phenomenon, we synthesized a series of 4-hydroxymethylpyrazoles V-VII: 1-(2-chloroethyl)-(V), 1-(2-chloroetbyl)-3-methyl- (VI) and 1-(2-chloroethyl)-5-methyl-4-hydroxymethylpyrazole(VII).