Synthesis, Antimicrobial Activity and Docking Studies of Novel 8-Chloro-quinolones

摘要

This paper presents experimental data regarding the synthesis of several quinolone derivatives. These compounds have been analyzed through physico-chemical techniques (elemental analysis, H-1-NMR,C-13-NMR, FT IR). The quinolone compounds were evaluated for "in vitro" activity by determination minimum inhibitory concentration against a varia of microorganisms. Molecular, topological, conformational characteristics on 3D quinolones optimized structure were calculated using Spartan 14 Software. Molecular docking approach, using CLC Drug Discovery Workbench Software was conducted in order to achieve accurate predictions on optimized conformation for both, the quinolone (as ligand) and their target receptor protein to form a stable complex, which is potentially able to improve quinolone biological activity.