A study of the viscosity of hyaluronic acid solutions for the preparation of polyelectrolyte complexes with chitosan

摘要

The viscosity of hyaluronic acid solutions kept at different pH values was found to decrease in the following order of pH: 6.5 > 3.5 > 4.3, although acid hydrolysis occurred at a higher rate in the most acidic solution. The poorest stability of the solutions with pH 4.3 was attributed to the compaction of the macromolecules as a result of charge density redistribution along the polyacid chains.