The recent application of approaches used to study somatic stem cells to the field of cancer biology has provided new insight into the nature of the cells and the molecular mechanisms that may be responsible for initiating or driving tumor progression. While this advance began with blood-borne cancers, it has quickly found applicability and relevance in solid tissue cancers, in particular one of the more aggressive of these types of cancers-the CNS-specific Glioblastoma Multiforme tumors. This is the most common adult brain tumor and has a poor prognosis despite current state-of-the-art treatments. In solving complex and difficult problems, a new perspective or methodological approach is always welcome, as it offers a fresh point of view, which may overcome long standing road blocks or provide novel solutions. It is with this in mind that we read the recent Resource article by Pollard and colleagues with great hope and interest (Pollard et al., 2009).
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