Endometrium cancer in a female with psoriatic arthritis treated with TNF alpha antagonist adalimumab.

摘要

Dear Sir,Psoriasis is the most common chronic and recurrent der-matologic disease, which affects approximately 2% of the population [1]. Many patients with psoriasis develop pso-riatic arthritis, a chronic inflammatory arthritis that causes progressive joint damage and increased mortality. Ada-limumab is a fully human anti-tumor necrosis factor monoclonal antibody demonstrated to be efficacious and safety in patients with psoriasis and psoriatic arthritis [2]. TNF (tumor necrosis factor) alpha is an important regulator of chronic inflammation and contributes to tumor progression. Therefore, questions have arisen about the potential risk of serious infections, including tuberculosis and malignancies with anti-TNF drugs [4].