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The control of crystallographic texture in the use of magnesium as a resorbable biomaterial

机译:使用镁作为可吸收生物材料时晶体结构的控制

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Magnesium and its alloys are an emerging class of resorbable materials for orthopedic and cardiovascular applications. The typical strategy underlying the development of these materials involves the control of material processing routes and the addition of alloying elements. Crystallographic texture is known to control bulk mechanical as well as surface properties. However, its role in determining the properties of magnesium for implant materials has not been well studied. In this work, an extruded rod of pure magnesium was cut in multiple directions to generate samples with different textures. It was found that texture significantly affected the strength and ductility of magnesium. Corrosion rates in Hank's solution decreased with the increased presence of low energy basal planes at the surface. In vitro cell studies revealed that changes in texture did not induce cytotoxicity. Thus, the control of texture in magnesium based implants could be used to tailor the mechanical properties and the resorption rates without compromising cytocompatibility. This study elucidates the importance of texture in the use of magnesium as a resorbable biomaterial.
机译:镁及其合金是一类新兴的可吸收材料,用于骨科和心血管领域。这些材料开发的典型策略涉及对材料加工路线的控制和合金元素的添加。已知晶体学织构可以控制整体机械性能和表面性能。然而,其在确定镁用于植入材料的性能方面的作用尚未得到很好的研究。在这项工作中,从多个方向切割了纯镁的挤压棒,以生成具有不同质地的样品。发现质地明显影响镁的强度和延展性。随着表面低能基平面的增加,汉克溶液的腐蚀速率降低。体外细胞研究表明,质地的变化不会引起细胞毒性。因此,镁基植入物的质地控制可用于调整机械性能和吸收速率,而不会损害细胞相容性。这项研究阐明了使用镁作为可吸收生物材料时质地的重要性。

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