Synergic effect of nano-catalyst and continuous flow system: Dakin-West reaction catalyzed by Nafion-H@SPIONs in a microreactor

摘要

The expansion of practical processes for superferromagnetic nano-catalysts is a very attractive subject. In this work, we successfully developed a new and efficient procedure with combination of continuous flow technology with immobilizing of only 0.35 mol% of Nafion-H on silica-encapsulated supperparamagnetic iron oxide nanoparticles (SPIONs) to maximize catalyst efficiency for the synthesis of beta-acetamido ketones. The turnover frequency value varies in the range of 1336 to 1577 h (1) compared to 256-515 h (1) in the conventional stirred reactor. Moreover, the catalyst could be quickly recovered by external magnetic field and could be reused for several reaction cycles without any change in its catalytic activity.