Interleukin-35 is upregulated in systemic sclerosis and its serum levels are associated with early disease

摘要

Objectives. IL-35 is a member of the IL-12 family consisting of p35/ IL-12a and EBI3/ IL-27b subunits. IL-35 exerts immunomodulatory activities in experimental and human autoimmune inflammatory conditions. Our aim was to assess IL-35 expression in the skin and circulation of SSc patients and to characterize its potential association with SSc-related features.