Tumor necrosis factor receptor-associated periodic syndrome P46L and bilateral amputation in diabetes.

摘要

Sir, TNF receptor (TNFR)-associated periodic syndrome (TRAPS) is an auto-inflammatory condition associated with defective TNFR mechanisms including retention of mutated TNFR in the endoplasmic reticulum, reduced activation-induced TNFR shedding and defective TNF-induced signalling and apoptosis [1]. Persistently elevated levels of TNF-alpha have been reported in wounds of persons with diabetes [2], and wound repair in rodent models of diabetes was improved by anti-TNF administration [3].