Swelling and thermodynamic studies of temperature responsive 2-hydroxyethyl methacrylate/itaconic acid copolymeric hydrogels prepared via gamma radiation

摘要

The copolymeric hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) were synthesized by gamma radiation induced radical polymerization.Swelling and thermodynamic properties of PHEMA and copolymeric P(HEMA/IA) hydrogels with different IA contents (2,3.5 and 5mol%) were studied in a wide pH and temperature range.Initial studies of so-prepared hydrogels show interesting pH and temperature sensitivity in swelling and drug release behavior.Special attention was devoted to temperature investigations around physiological temperature (37 °C),where small changes in temperature significantly influence swelling and drug release of these hswelling of hydrogels around 40 °C,the P(HEMA/IA) hydrogel containing 5mol% of IA without and with drug-antibiotic (gentamicin) were investigated at pH 7.40 and in the temperature range 25-42 °C,in order to evaluate their potential for medical applications.ydrogels.Due to maximum