Recent developments in nuclear data measurements and chemical separation methods in accelerator production of astatine and technetium radionuclides

摘要

The cyclotron produced neutron deficient technetiumradionuclides (~(93)Tc, ~(94)(m+g)Tc, ~(95)Tc, ~(96)Tc) have gainedrenewed interest in various fields, including nuclear imaging,provided they can be obtained in a pure form. Similarly, ~(211)Atdue to its moderate half-life and high intensity α-particleenergy (both from ~(211)At as well as its transient decay product~(211)Po) is of prime interest in targeted therapy. Another interestis to study the astatine chemistry, which is least studied comparedto other halogens due to its non-occurrence in naturalsystems. For maximum production of these radionuclides variousparameters need to be standardized. A chemical separationis required to achieve high radiochemical purity before in-vivoapplication. This review describes various production routesof neutron deficient astatine and technetium radionuclidesthat have been reported after the year 2000. The analyticalchemistry developed for separation of no-carrier-added (nca)Tc and At radionuclides in the same period is also discussedin detail.